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후보물질은 모낭의 멜라닌세포에 전달되어 멜라닌 형성에 중요한 역할을 하는 MITF의 기능을 왕성하게 만든다. 그 결과 멜라닌 합성을 촉진시켜 멜라닌 색소가 많아지고, 이 색소들이 각질 형성 세포에 전달되어 흰머리 개선을 유도한다.
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피부과 전공의사들을 통해 피나스테리드 복용과 우울감 간에 직접적인 인과관계가 밝혀진 바 없다는 점이 알려졌기 때문이다. 실제 대부분인 의료진들은 약 복용 보다는 탈모 자체로 인한 우울감 혹은 심리적 요인에 의해 보여지는 부작용인 ‘노시보 효과 가능성을 지적하고 있다.
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